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In particular, population dynamics of organisms can be altered by microplastic particles through trophic interactions 7, 8, such as bioaccumulation. Both marine and freshwater microplastic particles can impact ecosystem health 4, 5, 6. Microplastic particles (<5 mm in size) are widely distributed in all land and water ecosystems 1, 2, 3. Moreover, our analysis suggests that dynamic Lotka-Volterra models can play a vital role in predicting ecological impacts of microplastic particles on predator-prey population dynamics. Results of numerical simulations indicate the critical properties of the predator-prey system in response to microplastic particles: (i) predators are more vulnerable than prey under exposure to microplastic particles (ii) the effect of microplastic particles on prey and predator population growths can be negligible when toxicological response intensities of prey and predator are small (iii) this system is prey dependent for predator functional response, whose stability highly relies on the density of prey (iv) the reduced feeding capacity of prey and predator induced by microplastic particles does not significantly affect the population dynamics of the predator-prey system. In this study, using the Lotka-Volterra model, we theoretically investigated predator-prey population dynamics in terms of toxicological response intensity (strength to population growth rate) to microplastic particles, and examined the negative effects on prey feeding ability and predator performance due to microplastic particles. However, how microplastic particles affect prey and predator populations is not fully understood. Microplastic particles are widely distributed in a variety of ecosystems and can be transferred to predators along a food chain after being ingested by prey.